Can Prescription Medication Cause A False Positive?

Before you take a drug test, it’s important to answer the following question: Can prescription medication cause a false positive? The short answer — yes.


Here’s a list of medications that can cause a false positive:

  • Amitriptyline — can test positive for LSD
  • Bupropion (generic Wellbutrin) — can test positive for amphetamine, methamphetamine, and LSD
  • Dextromethorphan (found in Robitussin, Delsym and other over-the-counter cough medications) — can test positive for opiates and PCP
  • Diltiazem — can test positive for LSD
  • Diphenhydramine (Benadryl) — can test positive for LSD
  • Ibuprofen/Naproxen (Advil/Motrin and Aleve) — can test positive for barbiturates, THC (cannabinoid), and PCP.


And that’s just a few. Make sure to do your research before you go and get any type of blood work or drug testing done to ensure these false positives don’t happen to you.

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